Targeting the Power Plant

SS-31 (Elamipretide) is unique because it penetrates the cell and targets the inner mitochondrial membrane. Specifically, it binds to Cardiolipin, a phospholipid vital for the electron transport chain structure.

Oxidative stress damages cardiolipin, leading to “leaky” mitochondria that produce less energy (ATP) and more free radicals. SS-31 stabilizes cardiolipin, optimizing electron transfer. This restores ATP production and reduces oxidative damage, showing promise in treating heart failure, kidney disease, and general age-related fatigue.

Scientific References

  • Szeto HH. “First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics.” British Journal of Pharmacology. 2014.
  • Birk AV, et al. “The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin.” Journal of the American Society of Nephrology. 2013.