Central vs. Vascular

Drugs like Viagra work on the vascular system (blood flow). PT-141 (Bremelanotide) works on the central nervous system. By activating melanocortin receptors in the brain, it directly triggers sexual arousal and desire in both men and women.

Kisspeptin works upstream by stimulating the release of GnRH, which increases LH and FSH, leading to a natural boost in testosterone production. It is crucial for reproductive health and maintaining libido without shutting down natural hormone production.

Scientific References

  • Safarinejad MR. “Safety and efficacy of PT-141… in men with erectile dysfunction.” International Journal of Impotence Research. 2008.