The Sleep Architecture

Discovered in 1974, DSIP (Delta Sleep-Inducing Peptide) is a neuromodulator found in the brain. Its primary function is to promote Delta (Slow-Wave) Sleep, the deepest and most physically restorative stage of the sleep cycle.

A unlike sedatives that simply knock you out (often disrupting sleep architecture), DSIP appears to normalize the sleep cycle. Research also indicates it has stress-protective properties, reducing ACTH and cortisol levels, making it useful for insomnia driven by chronic stress.

Scientific References

  • Schoenenberger GA, Monnier M. “Characterization of a delta-electroencephalogram (sleep)-inducing peptide.” PNAS. 1977.
  • Kovalzon VM. “DSIP: a sleep peptide or a stress-protective factor?” Journal of Evolutionary Biochemistry and Physiology. 2018.